

Also, golf balls have cute little dimples.
Father, Hacker (Information Security Professional), Open Source Software Developer, Inventor, and 3D printing enthusiast


Also, golf balls have cute little dimples.


This is where I’d make all sorts of amazing accessories as an award-winning 3D modeler and designer…
IF I HAD A STEAM FRAME!
I’m probably in the 2027 camp 😭


The article concludes with this:
We would be doing a disservice to our users and our downstream fellow developers in the same way that a visual artist would be doing a disservice to their viewers or a musician would be doing a disservice to their listeners if they served them auto-generated filler instead of their own creative output.
You can personally select and fell all the trees used to build your house. You can cut and sculpt each 2x4 with chisels and a hand plane like a true artisan.
Or you could just buy lumber in bulk, toss the boards that have flaws, and build your house that way. What’s great about that is that as long as you follow building codes your home won’t just collapse at the first storm. It won’t just burn down with the drop of a match. It won’t leak and ruin your stuff.
Using LLMs to code is like buying lumber in bulk. Some of the boards that come off the truck will have flaws. Sometimes they’re so bad you can break the 2x4 over your knee! But the job of the builder/framer is to make sure those bad boards don’t get used. They’re spotted, marked, and replaced.
Code can be art! Absolutely! But not all code needs to be art. Not only that, but your employer doesn’t give a shit about how well-written any given code is so why bother? Just give them the AI output that works/passes tests and collect that paycheck.


Sure!
Disclaimer: This LitRPG comedy about a shapeshifter is a work of fiction. 😇👍
Possibly interesting: The following placebo-controlled clinical trials were for drugs that inhibited the microglial pathways (via p38 MAPK inhibitors and minocycline). They all failed:
There’s a problem with all of them: They failed to disaggregate results based on sex, which is exactly the problem I was talking about when I said “(we) need to account for (sex in medical studies)” earlier. This leads me to believe that these pain medications could have been useful for men, but probably not for women if the mouse studies indicating different pain pathways for each sex apply to humans.
There’s a whole article about this: https://doi.org/10.3389/fneur.2025.1730291
Historically, research has assumed a largely “sex-neutral” model of pain. Yet mounting evidence demonstrates that men and women differ substantially in pain perception, processing, and response to treatment (7–9). These differences span the entire biopsychosocial spectrum, including neural circuitry, immune function, hormonal regulation, genetics, and social context (10). Understanding these distinctions is critical, as failure to account for sex as a biological variable risks overlooking mechanisms unique to half of the population and may lead to suboptimal or even harmful therapeutic approaches.


Almost forgot: I posted my sources in this comment: https://programming.dev/post/57533861/26373477


For my sources, see this comment: https://programming.dev/post/57533861/26373477
If your genetics plays an important factor in pain, consider that your sex is “your genetics”, TubularTittyFrog.


It’ll be a while. I’m going to use it as the poster child for a new web novel publishing site I’m building.
I’ve already got much of the code written for the site, but I had to stop because I was thinking, “I should really write a story using all these features first so I know what works and what doesn’t.”
…and that’s the phase I’m currently at.
I have a draft written for the first two acts, so it won’t be forever but probably at least six months out.


Doh! You’re right. I had to dig deep into my old notes about this and here’s the papers:
Edit: Almost forgot the studies showing female (mammals) switch to the male pathway during pregnancy:
…and this study indicates that humans have the same genes associated with this sexual dimorphism:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10169414/?hl=en-US
Since it’s highly unethical to test pain pathways in humans, we have to rely on the mouse studies and extrapolate from there. The RNA testing shows we have the exact same genes as mice for pain expression, so the evidence lines up that men and women are using these different pathways for pain.
I didn’t just use “magical thinking” like I’ve of the other commenters suggested 🤷


Oh geeze, I’m not an expert in this stuff. I’m writing a novel about a PhD-level biologist (who becomes a shapeshifter) and ended up doing loads of research about biology… stuff in order to make the way he modifies people a bit more believable (so many stories are so full of hand waving these days it drives me nuts!).
One of the things I ended up researching was sexual dimorphism in various species including humans and wow what a rabbit hole that is! I have in my notes all sorts of things (differences) that most people have no clue about:
Hopefully that explains what I think I understand about the differences that lead up to women experiencing pain differently/more intensely.
…and that’s just scratching the surface of all the differences! People think men and women “are basically the same, just with a few physical differences” but it’s more like this: Men and women experience the world completely differently from each other.
Women physically see things differently than men (they see colors in greater resolution), they feel the world differently from men, and they have 50% more olfactory bulb neurons than men which means they have much more sensitive noses (especially to certain compounds like sulfur and scents like lavender have a vastly enhanced effect!).
Women live in a different world than men. We need to stop pretending we’re the same and start accounting for it in medical studies!


Well, yeah: Women use T cells to communicate pain through the neuro-immune pathways while men use microglia-to-BDNF (Brain-Derived Neurotrophic Factor). The women’s version of pain completely bypasses all of that, jumping straight to pro-inflammatory cytokines that increase sensitivity.
Unless the woman is pregnant. Then she’ll use the same exact pain pathways as men. Presumably, to make the pain of childbirth not-as-bad.
Bismuth also has the added advantage of being able to cure your upset stomach,. diarrhea, indigestion/acid reflux!
You just have to dissolve the round in hot nitric acid, then separate the white (tin) crystals that form (after an hour of keeping it hot) by pouring the resulting liquid through an acid-resistant paper filter (or a fancy glass microfiber), and finally react the purified bismuth solution with salicylic acid and BAM! DIY Pepto Bismol 👍